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Minggu, 25 Mei 2014

[P460.Ebook] Fee Download Antibiotics: Challenges, Mechanisms, Opportunities, by Christopher Walsh, Timothy Wencewicz

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A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance

Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.

This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.

Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:

What are antibiotics?
Where do antibiotics come from?
How do antibiotics work?
Why do antibiotics stop working?
How should our limited inventory of effective antibiotics be addressed?

Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

Sales Rank: #483303 in Books
Published on: 2016-02-05
Original language: English
Number of items: 1
Dimensions: 10.10" h x .90" w x 7.20" l, .0 pounds
Binding: Hardcover
477 pages

Review
This book provides all the information needed to understand antibiotic genetics, biochemistry, mechanism of action and resistance. Most importantly, Walsh & Wencewicz are optimistic of the prospects of the discovery of novel therapeutic agents obtained by the manipulation of strains and biosynthetic pathways. This beautifully written book deserves to be read and implemented by everyone, especially the pessimists who believe that the antibiotic era has ended. In Antibiotics: Challenges, Mechanisms, Opportunities, Walsh & Wencewicz provide the definitive, ultimate compendium of everything antibiotic. --Julian Davies, Professor of Microbiology and Immunology, Life Sciences Institute, University of British Columbia Vancouver

From the Inside Flap
"A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: [[ What are antibiotics? [[ Where do antibiotics come from? [[ How do antibiotics work? [[ Why do antibiotics stop working? [[ How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists. "

About the Author
Christopher Walsh is a Harvard Medical School professor emeritus who serves as a senior advisor to the ChEM-H Center at Stanford University. He has authored hundreds of papers and books, including the predecessor to this title, Antibiotics: Origins, Actions, Resistance (2003). Dr. Walsh is a member of the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society and a co-recipient of the 2010 Welch Prize in Chemistry.

Timothy Wencewicz is a faculty member in the Department of Chemistry at Washington University in St. Louis. After receiving his PhD at the University of Notre Dame, he was a postdoctoral fellow in Christopher Walsh s laboratory at the Harvard Medical School. Dr. Wencewicz s research centers on antibiotic drug discovery, natural product biosynthesis, and targeted drug delivery across bacterial membranes.

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Jumat, 23 Mei 2014

[N395.Ebook] Download PDF The Woods: A Drama, by David Mamet

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The Woods: A Drama, by David Mamet

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Includes a scene design page. 64pp.

Sales Rank: #1548855 in Books
Published on: 1979
Format: Import
Original language: English
Number of items: 1
Binding: Paperback
64 pages

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0 of 1 people found the following review helpful.
One Star
By Loralei G.
Marked up like crazy. Not good.

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Minggu, 18 Mei 2014

[S692.Ebook] Download Consumer Behavior: Building Marketing Strategy, by Delbert Hawkins, David Mothersbaugh, Roger Best

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Consumer Behavior: Building Marketing Strategy, by Delbert Hawkins, David Mothersbaugh, Roger Best

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This book is a strategic look at consumer behavior in order to guide successful marketing activities. The Wheel of Consumer Analysis is the organizing factor in the book. The four major parts of the wheel are consumer affect and cognition, consumer behavior, consumer environment, and marketing strategy. Each of these components is the topic of one of the four major sections in the book.

Sales Rank: #330307 in Books
Brand: Brand: McGraw-Hill/Irwin
Published on: 2009-01-30
Original language: English
Number of items: 1
Dimensions: 12.00" h x .1" w x 8.50" l, .0 pounds
Binding: Hardcover
832 pages

Features

Used Book in Good Condition

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6 of 7 people found the following review helpful.
Decent book, but lacking in some areas
By skibunne
This was a required text from an undergraduate Consumer Behavior course. While the book contains a lot of good information, it is baffling to me how it is in its eleventh print and still doesn't contain a glossary of the vocabulary words. Some of the vocabulary words are bolded, but never explicitly defined in the text. There are not vocab definitions in the margins even. This was frustrating for someone, such as myself and several classmates I talked to, who rely on concisely defined vocabulary words as study material, and for creating vocab flash cards. It's just an additional hassle after reading the text to have to go back and basically create my own definitions for some of the words.

I also found a spelling error and a few minor grammatical errors. Again, not what I'd expect from an eleventh edition $120 textbook.

4 of 5 people found the following review helpful.
Okay...
By Brian J. Reich
This book was absolutely full of information. However, much of the text seemed repetitive and drab. Good material when partnered with a good instructor, but the text could be a bit more interesting.

1 of 1 people found the following review helpful.
Yawn. Gives textbooks an even worse name
By C. A. Raymond
I long since acquired my PhD in sociology, but have been sitting in on a marketing class at the university where I work. This is the required text.

Its painfully yawn-inducing writing style along with a mediocre-at-best book design has prompted me to return my rental. It is actually psychically painful for me to sit down and read a chapter. The text meanders, has no narrative thread, and the typographic and layout design is poor. And to think students are expected to cough up more than $100 for this insomnia cure.

Surely, with all the creative minds in the marketing community, someone could write an appealing book that could be used as a textbook. I'm now in search of something with both substance and style.

This is NOT it.

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[O389.Ebook] Free Ebook The Genius of Dogs: How Dogs Are Smarter Than You Think, by Brian Hare, Vanessa Woods

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For readers of Inside of a Dog by Alexandra Horowitz, this New York Times bestseller offers mesmerizing insights into the interior lives of our smartest pets

In the past decade, we have learned more about how dogs think than in the last century. Breakthroughs in cognitive science, pioneered by Brian Hare, have proven dogs have a kind of genius for getting along with people that is unique in the animal kingdom. This dog genius revolution is transforming how we live and work with our canine friends, including how we train them. Does your dog feel guilt? Is she pretending she can't hear you? Does she want affection—or just your sandwich? In Th�e Genius of Dogs, Brian Hare and Vanessa Woods lay out what discoveries at the Duke Canine Cognition Lab and other research facilities around the world are revealing about how your dog thinks and how we humans can have even deeper relationships with our best four-legged friends.

Sales Rank: #28091 in Books
Published on: 2013-10-29
Released on: 2013-10-29
Original language: English
Number of items: 1
Dimensions: 8.00" h x .80" w x 5.20" l, .65 pounds
Binding: Paperback
384 pages

Most helpful customer reviews

96 of 107 people found the following review helpful.
Almost awesome: The good, the bad, the ugly
By movingwordsandimages
I bought this book because Victoria Stilwell recommended it. In fact, treat trainer that she can be, I'd love to read her honest and full review of this book if one is available...

This book is really quite engaging from the beginning through halfway into the read. The essays build a case, chapter by chapter, towards the most fascinating part (in my opinion) called "Survival of the Friendliest," which looks at the evolution of dogs - and humans - in a way that I've never heard of. It really is fantastic food for thought.

However, the book's title points to another supposedly revelatory finding in the area of dog cognition or "dognition." And, having finally arrived at its application for us dog owners/handlers, the section was disappointingly thin, just one chapter titled "Teaching Genius" that runs about 30 pages. And this came at the unnecessary expense of pitting itself against Behaviorism (a.k.a. reward-based training or clicker training). There's even a section very unfortunately named "The Tyranny of Behaviorism." Really, tyranny?

This poor choice of words and perspective really does the author's writing a disservice. Behavioral training has done A LOT to advance the methodologies of the everyday trainer. For generations prior, well-meaning but totally misinformed people applying Dominance theory were beating and choking their dogs half to death. The Behavioral approach has given tools that regular people (not just elite scientists and researchers) can understand and use. It's proven to work, it's safe, and has improved the relationships of many households with their pets. How is that tyranny?

Better for this book had the author added dognition as an interesting, fresh, and nuanced layer to what Behavioral training has clearly accomplished. Instead, he goes in like a bullheaded academic claiming everyone else is wrong, and this undermines his efforts. Especially since: he admits there's still a lot of work to do / findings to uncover, a bunch of his examples are personal anecdotes (not rigorous science), and in some cases plainly open to interpretation.

For instance, there is a big claim that dogs can spontaneously learn things and take cues from humans. But many of the examples required using a family pet or service dog or teaching a dog the setup of a particular game, which means they've all already received tons of information from humans prior to the experiment. I had a hard time seeing how this was clear evidence of "spontaneous" learning. And it was also obvious that the genius dogs that were described were certainly exceptions. I tried to get my own dog to "spontaneously" learn some vocabulary as well as use pointing gestures to clue him to hidden treats. And these didn't quite work the way the book described.

Well, to be realistic, maybe I did it wrong. But that goes back to my initial critique. This concept is too new, perhaps premature, even woefully overconfident, to offer any updated training techniques, let alone assert that it has the authority to totally REPLACE a well studied and substantiated method; i.e. Behavioral training.

On top of that, the dognition suggestion (especially without a proper instruction/teaching manual) that your dog "knows" to be sneaky or disobedient creeps dangerously close to the thought processes of those that still hold to the picture of the hyper-anthropomorphized dog in Dominance theory. Sure, all of our dogs can be naughty or clever in inconvenient ways, but does it help us to look at them with added suspicion, that they have a conscience that deliberately breaks the known rules? The answer is no. Until Dognition can flesh out its ideas, intention, and practices, I don't believe "The Genius of Dogs" is reading that would add to most people's training toolkits.

Let me be clear. I don't recommend against reading this book, thus the fair 3-star rating. As I mentioned, the evolutionary theory is great stuff. But you must take it all in with a grain of salt. This book could have been 5 stars if the author sought to build upon rather than bash current expertise.

And certainly, if you're only beginning to read books about dogs, there are other titles I would recommend first. Like For the Love of a Dog: Understanding Emotion in You and Your Best Friend. Or The Other End of the Leash: Why We Do What We Do Around Dogs. Yes, written by a dreaded Behaviorist, but also an accomplished trainer and researcher, Patricia McConnell. Plus, these books no less take on some of the same subject matter! Just without the restrictive viewpoint.

89 of 99 people found the following review helpful.
Best Book on Dogs!
By V.Morell
Dog owners know their dogs are smart. Yet they were banned from animal cognition studies for years; researchers thought they must not be very bright because they were domesticated animals. But, as Brian Hare and Vanessa Woods show in this highly engaging and insightful book, dogs are really geniuses. They're not soft and dim compared to their wild wolf cousins--they're geniuses! Why? Because, as the authors write, dogs "were smart enough to come in from the cold and become part of the [human] family." Their book presents the latest studies on dog smarts, and you'll come away with a new appreciation for your pooch--and the scientists who broke away from their own pack to investigate the minds of our best and brightest friends.

35 of 37 people found the following review helpful.
Science Goes to the Dogs
By Rob Hardy
Here is a book of real, cutting-edge science that will be accessible to anyone. It's reporting of genuine scholarship, it describes experiments in detail, it has graphs, and it's got seventy pages of footnotes at the end. The reason the science here goes down so easily is simply the subject matter. _The Genius of Dogs: How Dogs Are Smarter Than You Think_ (Dutton) is by the founder of the Duke Canine Cognition Center Brian Hare and his wife Vanessa Woods, a research scientist at the center. It tells about how dogs got to be partners with humans with advantages to both sides, what dogs can figure out and how, what dog breeds are smartest, and much more. The book is written in the first person with Hare being the person; he affably describes how much he learned as a kid from his dog Oreo. A professor told him that chimpanzees could not understand human gestures, and Hare blurted out, "My dog can do that!" The professor didn't shut him up, but encouraged him to do research, and Oreo was his first subject. The book invites all of us to have some scientific fun learning what our dogs can do, and the authors have set up a website to help with home research that will supply broad-based data for their team.

The experiments described here are fascinating, all the more so because there is a "try this at home" attitude. It is surprising how involved the research had to be in order meticulously to weed out alternative explanations. For instance, Oreo had a choice of two cups, under one of which was a treat. Naturally, Hare the experimenter had not put food under one without faking putting food under the other. He settled himself between the two cups, and pointed to the one hiding the food. "Okay, Oreo, go find it!" he said, and Oreo went to the cup pointed at. But the experiment had to be re-done in ways that showed Oreo was not simply sniffing his way to the right cup rather than following a point. Maybe Oreo was associating the pointing hand with food and merely going to the cup closest to the pointing finger. Maybe he was just responding to a motion, with no idea that it was a point. Maybe he could respond to Hare's point but would know nothing about the point of some other human. Or maybe training and playing catch made Oreo a genius at following points, whereas an "ordinary" dog would be unable to. The fascinating experiments show that indeed, dogs understand gestures made by humans and they are born understanding, without having to be trained.

There are plenty of other "genius" abilities examined here, but the key is that dogs got themselves into a niche where not only did being responsive to gesture prove directly useful (Oreo got the treat), but also it secured them in a comfortable relationship. We like it that our dogs are so "in tune" with what we are doing and that they pay us such close attention, so we take care of them. There are no other species that spontaneously read our gestures as well as dogs can, and by such means, dogs have become our partners for hunting, or leading the blind, or sniffing out bombs, or just being close, attentive friends.

There are illuminating pages here on canine characteristics that will interest any dog lover. Some dogs are smarter than others, but what breeds are smarter? It is not a question that science has a current answer for (although many dog owners will propose their favorite breed as smartest); there are so many breeds, and there is little agreement about what a breed really is. There's only rudimentary research on the question so far, but it seems unlikely that there will be big differences between breeds. Are pit bulls aggressive? No, and plenty of dogs that look like pit bulls are something else entirely anyway. Can dogs feel guilt? No; experiments showed that a disapproving voice or gestures from an owner would produce subservient behavior that looked like an admission of guilt, whether the dog had done wrong or not. There's lots of news in this book, a perfect illustration of how looking at something scientifically can only increase our wonder and delight at it.

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Jumat, 16 Mei 2014

[T181.Ebook] Free PDF "Windsor Fair" Windsor, Maine: A history of the first 100 years, by Earle R Hayes

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Published on: 1989
Binding: Unknown Binding
93 pages

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Kamis, 15 Mei 2014

[M908.Ebook] Free Ebook Nucleated Villages A Strategy For Rural Development In Northern Uganda: Lessons Learned From The Northern Uganda Conflict 1st EditionBy

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Detailed exploration of the this methodology and potential for rural development from its ashes after protracted military conflict into a model agricultural economy is the mandate of this book. Drawing from examples from developed economies as well as the immerging and developing regions, this compelling and comprehensive essay on the reorganization of Uganda sets out to demonstrate the importance of nucleation of large agrarian communities as a means of achieving sustainable rural development in present day Africa. The practical ideas presented by the author makes this book an important read for all those committed to rural African development. Working with local government structures, Ocitti plans what will no doubt become the backbone of the much needed Northern Uganda and indeed Uganda and African's agricultural, economical, social and cultural reform.

Sales Rank: #11900672 in Books
Published on: 2011-08-04
Original language: English
Number of items: 1
Dimensions: 9.00" h x .57" w x 6.00" l, .74 pounds
Binding: Paperback
224 pages

About the Author
Silver Ocitti earned a first class honors Bachelor of Architecture degree from University of Nairobi in 1977 and a Master of Philosophy in Urban and Rural design from Edinburgh University, Britain in 1981. In 1983 he established a planning, architecture and interior design firm with offices in Nairobi and Kampala, handling numerous projects within the region. Mr. Ocitti's special interest in rural development was fanned by the various political conflicts in Uganda that disastrously affected the rural regions. He served as a board member in three organizations that attempted to address these rural dilemmas. Presently under the Charles Owor Foundation, named after his prominent late brother with whom he served in the rural organizations, he is addressing the concept of nucleated village as viable sustainable developmental solutions to the devastated rural areas in Uganda. In addition to his profession as a rural planner and architect, Mr. Ocitti being a highly talented person was a pioneer in promoting modern gospel music in East Africa. He has recorded three Gospel music albums since the seventies. He is a poet and an artist. He owns a furniture and interior design company, the Feel of Africa Ltd. that had a large showroom in Kampala. Currently Ocitti has concentrated in interior design contracts and the exporting of interior items abroad. Mr. Ocitti is also a farmer. He has developed the first cranberry farm in the region. Mr. Ocitti is a leader in his church. He is married to his lovely wife, Harriet Ocitti with whom he partners in multi-level marketing and interior design export. He has three home-schooled teen-age children, Lamar, Lagen and Lamich.

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Selasa, 13 Mei 2014

[C137.Ebook] Download PDF The Recorder Guide, by Johanna E. Kulbach, Arthur Nitka

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Music book

Sales Rank: #1971912 in Books
Published on: 1965
Original language: English
Binding: Plastic Comb

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0 of 0 people found the following review helpful.
This is a great book
By Happy Carvin Jack
They do a wonderful job of showing the C and F music side by side. This makes learning the alto after knowing the soprano much easier.
Great step by step instruction.

Product arrived quickly.

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